San Giovanni in Rome is generally safe for visitors both during the day and at night, especially in well-populated areas. However, as with any major city, be mindful of common tourist scams, such as individuals asking for donations or offering unsolicited assistance, which may lead to pressure tactics. Areas around busy tourist spots can attract pickpockets, so keep your belongings secure and be cautious in crowded situations. For solo travelers, it's wise to stay aware of your surroundings, avoid poorly lit streets at night, and consider joining group activities to enhance safety and meet others. Always trust your instincts and seek help if something feels off.