Centro Storico in Rome is generally safe to visit both during the day and at night, attracting many tourists. However, like any popular tourist area, it's wise to stay vigilant against common scams, such as individuals asking for donations or street performers who may pressure you for money. Be cautious around crowded areas and public transport, where pickpocketing can occur, particularly near popular attractions like the Pantheon and Piazza Navona. For solo travelers, consider joining guided tours, stay aware of your surroundings, and avoid poorly lit streets at night to enhance your safety while enjoying the historic sites of the area.