Skip the line Colosseum & Vatican Museums, Hotel Pick-up Drop-off, Tkts included

Founded by Pope Julius II in the early 16th century and enlarged by successive pontiffs, the Vatican Museums boast one of the world's greatest art collections. Exhibits, which are displayed along about 7km of halls and corridors, range from Egyptian mummies and Etruscan bronzes to ancient busts, old masters and modern paintings. Highlights include the spectacular collection of classical statuary in the Museo Pio-Clementino, a suite of rooms frescoed by Raphael, and the Michelangelo-painted Sistine Chapel.

The Sistine Chapel takes its name from Pope Sixtus IV della Rovere (pontiff from 1471 to 1484) who had the old Cappella Magna restored between 1477 and 1480. The 15th century decoration of the walls includes: the false drapes, the Stories of Moses (south and entrance walls) and of Christ (north and entrance walls) and the portraits of the Popes (north and south and entrance walls). It was executed by a team of painters made up initially of Pietro Perugino, Sandro Botticelli, Domenico Ghirlandaio and Cosimo Rosselli, assisted by their respective shops and by some closer assistants among whom Biagio di Antonio, Bartolomeo della Gatta and Luca Signorelli stand out. On the Ceiling Pier Matteo d'Amelia painted a starry sky. The work on the frescoes began in 1481 and was concluded in 1482.